abstract：BACKGROUND:Few studies have longitudinally examined predictors of posttraumatic stress disorder (PTSD) in a nationally representative sample of US veterans. We examined predictors of warzone-related PTSD over a 25-year span using data from the National Vietnam Veterans Longitudinal Study (NVVLS). METHODS:The NVVLS is ...

journal_title：Depression and anxiety

authors： Steenkamp MM,Schlenger WE,Corry N,Henn-Haase C,Qian M,Li M,Horesh D,Karstoft KI,Williams C,Ho CL,Shalev A,Kulka R,Marmar C

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that posttraumatic stress disorder (PTSD) is associated with disrupted default mode network (DMN) connectivity, but findings across studies have not been uniform. Individual differences in relevant genes may account for some of the reported variability in the relationship betwe...

journal_title：Depression and anxiety

authors： Miller DR,Logue MW,Wolf EJ,Maniates H,Robinson ME,Hayes JP,Stone A,Schichman S,McGlinchey RE,Milberg WP,Miller MW

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Increased psychophysiological reactivity is a hallmark intermediate phenotype of posttraumatic stress disorder (PTSD). Individuals with PTSD exhibit greater skin conductance (SC) responses to trauma scripts than trauma survivors without PTSD. However, trauma scripts require time for development and cannot be...

journal_title：Depression and anxiety

authors： Hinrichs R,Michopoulos V,Winters S,Rothbaum AO,Rothbaum BO,Ressler KJ,Jovanovic T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Exposure therapy, a gold-standard treatment for anxiety disorders, is assumed to work via extinction learning, but this has never been tested. Anxious individuals demonstrate extinction learning deficits, likely related to less ventromedial prefrontal cortex (vmPFC) and more amygdala activation, but the rela...

journal_title：Depression and anxiety

authors： Ball TM,Knapp SE,Paulus MP,Stein MB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Depression and anxiety have been related to poorer self-reported physical functioning over time; however, objective measures of physical function are less frequently examined. This study assessed the 6-year trajectory of hand-grip strength and lung function in persons with depressive and/or anxiety disorders...

journal_title：Depression and anxiety

authors： Lever-van Milligen BA,Lamers F,Smit JH,Penninx BW

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Depression is a highly prevalent disease with a high morbidity and mortality risk. Its pathophysiology is not entirely clear. However, type 2 diabetes is an important risk factor for depression. One mechanism that may explain this association may include the formation of advanced glycation end products (AGEs...

journal_title：Depression and anxiety

authors： van Dooren FE,Pouwer F,Schalkwijk CG,Sep SJ,Stehouwer CD,Henry RM,Dagnelie PC,Schaper NC,van der Kallen CJ,Koster A,Denollet J,Verhey FR,Schram MT

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Major depressive disorder (MDD) has been associated with changes in mean telomere length and mitochondrial DNA (mtDNA) copy number. This study investigates if clinical features of MDD differentially impact these molecular markers. METHODS:Data from a large, clinically ascertained sample of Han Chinese women...

journal_title：Depression and anxiety

authors： Edwards AC,Aggen SH,Cai N,Bigdeli TB,Peterson RE,Docherty AR,Webb BT,Bacanu SA,Flint J,Kendler KS

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, tr...

journal_title：Depression and anxiety

authors： Gold AL,Shechner T,Farber MJ,Spiro CN,Leibenluft E,Pine DS,Britton JC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Internet-delivered cognitive behavioral therapy (iCBT) is a relatively novel treatment method that may improve the accessibility of mental health care for individuals with posttraumatic stress disorder (PTSD). The aim of this meta-analysis was to evaluate the effectiveness of iCBT compared to inactive (waitl...

journal_title：Depression and anxiety

authors： Sijbrandij M,Kunovski I,Cuijpers P

更新日期：2016-09-01 00:00:00

abstract：:There is an urgent need for more rapidly effective pharmacotherapies for major depressive disorder and bipolar disorder (BP) that are efficacious and tolerable for depressed patients who respond poorly to conventional treatments. Multiple controlled trials have now demonstrated a rapid, nonsustained antidepressive res...

journal_title：Depression and anxiety

authors： Bobo WV,Vande Voort JL,Croarkin PE,Leung JG,Tye SJ,Frye MA

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Reducing access to lethal means (especially firearms) might prevent suicide, but counseling of at-risk individuals about this strategy may not be routine. Among emergency department (ED) patients with suicidal ideation or attempts (SI/SA), we sought to describe home firearm access and examine ED provider ass...

journal_title：Depression and anxiety

authors： Betz ME,Miller M,Barber C,Beaty B,Miller I,Camargo CA Jr,Boudreaux ED

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Little is known about the association between trauma exposure and suicidal ideation across racial/ethnic groups. Our study aim was to determine the association between trauma exposure and suicidal ideation in a nationally representative ethnically diverse sample of adults. METHODS:This study included 14,866...

journal_title：Depression and anxiety

authors： Beristianos MH,Maguen S,Neylan TC,Byers AL

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Brain structures underlying posttraumatic stress disorder (PTSD) have been a focus of imaging studies, but associations between treatment outcome and alterations in brain structures remain largely unexamined. We longitudinally examined the relation of structural changes in the rostral anterior cingulate cort...

journal_title：Depression and anxiety

authors： Helpman L,Papini S,Chhetry BT,Shvil E,Rubin M,Sullivan GM,Markowitz JC,Mann JJ,Neria Y

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that mindfulness may be an effective component for posttraumatic stress disorder (PTSD) treatment. Mindfulness involves practice in volitional shifting of attention from "mind wandering" to present-moment attention to sensations, and cultivating acceptance. We examined potential neural...

journal_title：Depression and anxiety

authors： King AP,Block SR,Sripada RK,Rauch S,Giardino N,Favorite T,Angstadt M,Kessler D,Welsh R,Liberzon I

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Hypothalamic-pituitary-adrenal (HPA) axis functioning has been implicated in the development of stress-related psychiatric diagnoses and response to adverse life experiences. This study aimed to investigate the association between genetic and epigenetics in HPA axis and response to cognitive behavior therapy...

journal_title：Depression and anxiety

authors： Roberts S,Keers R,Lester KJ,Coleman JR,Breen G,Arendt K,Blatter-Meunier J,Cooper P,Creswell C,Fjermestad K,Havik OE,Herren C,Hogendoorn SM,Hudson JL,Krause K,Lyneham HJ,Morris T,Nauta M,Rapee RM,Rey Y,Schneider S

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Axis I comorbidity complicates diagnosing axis II personality disorders (PDs). PDs might influence Axis I outcome. No research has examined psychotherapy effects on PDs of treating Axis I comorbidity. Secondary analysis of a randomized controlled trial examined PD diagnostic stability after brief psychothera...

journal_title：Depression and anxiety

authors： Markowitz JC,Petkova E,Biyanova T,Ding K,Suh EJ,Neria Y

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Oligodendrocyte transcription factor 2 (OLIG2) is primarily concentrated in the brain and spinal cord ventricular zone, where this protein stimulates oligodendrocytes and specific neurons, determines motor neuron and oligodendrocyte differentiation, and sustains replication in early development. Recent studi...

journal_title：Depression and anxiety

authors： Zhang X,Liu J,Guo Y,Jiang W,Yu J

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Processes of phasic fear responses to threatening stimuli are thought to be distinct from sustained, anticipatory anxiety toward an unpredicted, potential threat. There is evidence for dissociable neural correlates of phasic fear and sustained anxiety. Whereas increased amygdala activity has been associated ...

journal_title：Depression and anxiety

authors： Münsterkötter AL,Notzon S,Redlich R,Grotegerd D,Dohm K,Arolt V,Kugel H,Zwanzger P,Dannlowski U

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:The clinical presentation of panic disorder (PD) is known to be highly heterogeneous, complicating research on its etiology, neurobiological pathways, and treatment. None of the attempts to identify PD subtypes have been independently reproduced, rendering the current literature inconclusive. METHODS:Using ...

journal_title：Depression and anxiety

authors： Pattyn T,Van Den Eede F,Lamers F,Veltman D,Sabbe BG,Penninx BW

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Diagnostic criteria for DSM-5 posttraumatic stress disorder (PTSD) are in many ways similar to DSM-IV criteria, raising the possibility that it might be possible to closely approximate DSM-5 diagnoses using DSM-IV symptoms. If so, the resulting transformation rules could be used to pool research data based o...

journal_title：Depression and anxiety

authors： Rosellini AJ,Stein MB,Colpe LJ,Heeringa SG,Petukhova MV,Sampson NA,Schoenbaum M,Ursano RJ,Kessler RC,Army STARRS Collaborators.

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Vilazodone, a selective serotonin reuptake inhibitor and 5-HT1A receptor partial agonist, is approved for treating major depressive disorder in adults. This study (NCT01629966 ClinicalTrials.gov) evaluated the efficacy and safety of vilazodone in adults with generalized anxiety disorder (GAD). METHODS:A mul...

journal_title：Depression and anxiety

authors： Gommoll C,Durgam S,Mathews M,Forero G,Nunez R,Tang X,Thase ME

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is highly familial, but studies have yet to examine preschoolers at risk for BD using standardized, developmentally appropriate clinical assessment tools. We used such methods to test whether preschoolers at familial risk for BD have more observed difficulty modulating emotions and beha...

journal_title：Depression and anxiety

authors： Tseng WL,Guyer AE,Briggs-Gowan MJ,Axelson D,Birmaher B,Egger HL,Helm J,Stowe Z,Towbin KA,Wakschlag LS,Leibenluft E,Brotman MA

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Adolescent suicide attempts are disproportionally prevalent and frequently of low severity, raising questions regarding their long-term prognostic implications. In this study, we examined whether adolescent attempts were associated with impairments related to suicidality, psychopathology, and psychosocial fu...

journal_title：Depression and anxiety

authors： Brière FN,Rohde P,Seeley JR,Klein D,Lewinsohn PM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Understanding cognitive and biological mechanisms of PTSD treatment can help refine treatments and increase rates of response. METHODS:Thirty-six veterans with PTSD were randomly assigned to receive Prolonged exposure therapy (PE) or Present-Centered therapy (PCT). We examined symptoms, trauma-related cogni...

journal_title：Depression and anxiety

authors： Rauch SA,King AP,Abelson J,Tuerk PW,Smith E,Rothbaum BO,Clifton E,Defever A,Liberzon I

更新日期：2015-03-01 00:00:00

abstract：:Internet-delivered cognitive behavioral therapy (iCBT) was developed to overcome some of the barriers in accessing best practice face-to-face CBT. iCBT affords many benefits, such as high fidelity, greater accessibility, convenience, and reduced cost to patients and health-care systems. Recent meta-analyses of iCBT fo...

journal_title：Depression and anxiety

authors： Andrews G,Williams AD

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Collectively, functional neuroimaging studies implicate frontal-limbic dysfunction in the pathophysiology of posttraumatic stress disorder (PTSD), as reflected by altered amygdala reactivity and deficient prefrontal responses. These neural patterns are often elicited by social signals of threat (fearful/angr...

journal_title：Depression and anxiety

authors： Rabinak CA,MacNamara A,Kennedy AE,Angstadt M,Stein MB,Liberzon I,Phan KL

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Comorbid psychiatric disorders, cardiovascular disease, chronic hypertension, diabetes, and musculoskeletal disorders are highly prevalent in depression. However, the extent to which these conditions affect the recurrence of depression-related work disability is unknown. The specific aims of the study were t...

journal_title：Depression and anxiety

authors： Ervasti J,Vahtera J,Pentti J,Oksanen T,Ahola K,Kivekäs T,Kivimäki M,Virtanen M

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...

journal_title：Depression and anxiety

authors： IsHak WW,Mirocha J,Christensen S,Wu F,Kwock R,Behjat J,Pi S,Akopyan A,Peselow ED,Cohen RM,Elashoff D

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:We used a dot-probe paradigm to examine attention bias toward threat (i.e., angry) and happy face stimuli in severe mood dysregulation (SMD) versus healthy comparison (HC) youth. The tendency to allocate attention to threat is well established in anxiety and other disorders of negative affect. SMD is charact...

journal_title：Depression and anxiety

authors： Hommer RE,Meyer A,Stoddard J,Connolly ME,Mogg K,Bradley BP,Pine DS,Leibenluft E,Brotman MA

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The relationship between comorbidity and psychological distress is well documented, however the mechanism of this association is unclear. We aim to assess the extent to which the association between common chronic conditions and high scores on the Kessler Psychological Distress Scale (K10) measure of psychol...

journal_title：Depression and anxiety

authors： Byles JE,Robinson I,Banks E,Gibson R,Leigh L,Rodgers B,Curryer C,Jorm L

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVES:Comparing the overall and differential effects of psychodynamic psychotherapy (PDT) versus cognitive behavior therapy (CBT) for social anxiety disorder (SAD). DESIGN:Patients with a primary SAD (N = 47) were randomly assigned to PDT (N = 22) or CBT (N = 27). Both PDT and CBT consisted of up to 36 sessions (...

journal_title：Depression and anxiety

authors： Bögels SM,Wijts P,Oort FJ,Sallaerts SJ

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Metacognitive therapy (MCT) is a relatively new approach to treating mental disorders. The aim of the current meta-analysis was to examine the efficacy of MCT in patients with mental disorders. METHOD:A comprehensive literature search revealed 16 published as well as unpublished studies on the efficacy of M...

journal_title：Depression and anxiety

authors： Normann N,van Emmerik AA,Morina N

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Preliminary evidence suggests intravenous ketamine has rapid effects on suicidal cognition, making it an attractive candidate for depressed patients at imminent risk of suicide. In the first randomized controlled trial of ketamine using an anesthetic control condition, we tested ketamine's acute effects on e...

journal_title：Depression and anxiety

authors： Price RB,Iosifescu DV,Murrough JW,Chang LC,Al Jurdi RK,Iqbal SZ,Soleimani L,Charney DS,Foulkes AL,Mathew SJ

更新日期：2014-04-01 00:00:00

abstract：:An impediment to progress in mood disorders research is the lack of analytically valid and qualified diagnostic and treatment biomarkers. Consistent with the National Institute of Mental Health (NIMH)'s Research Domain Criteria (RDoC) initiative, the lack of diagnostic biomarkers has precluded us from moving away from...

journal_title：Depression and anxiety

authors： Niciu MJ,Mathews DC,Nugent AC,Ionescu DF,Furey ML,Richards EM,Machado-Vieira R,Zarate CA Jr

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Little is known regarding changes in the hypothalamic-pituitary-adrenal axis (HPA axis) of adolescent girls with and without posttraumatic stress disorder (PTSD) who have recently experienced sexual abuse. Therefore, in this pilot study, we utilized non-stressed home saliva collection three times a day for t...

journal_title：Depression and anxiety

authors： Keeshin BR,Strawn JR,Out D,Granger DA,Putnam FW

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:A history of past major depressive episodes (MDEs) is known to be a risk factor for future MDEs. Additional information about the relationship between past and future episodes would be useful in clinical practice, it is therefore important to fully understand the epidemiology of major depression. We asked wh...

journal_title：Depression and anxiety

authors： Bulloch A,Williams J,Lavorato D,Patten S

更新日期：2014-01-01 00:00:00

abstract：:There are well-established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited b...

journal_title：Depression and anxiety

authors： Uddin M,Sipahi L,Li J,Koenen KC

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Smoking in patients with bipolar disorder is known to be related to suicidality. This link has not been investigated, however, in community-based samples. The aim of this study is to delineate the sociodemographic and clinical characteristics of bipolar smokers and examine the relationship between these char...

journal_title：Depression and anxiety

authors： Baek JH,Eisner LR,Nierenberg AA

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:The impact of childhood adversity persists across the life course. This study aimed to investigate the associations of childhood adversity with the course, suicidality, and treatment outcomes of depressive disorders. METHOD:A total of 919 people with depressive disorders were recruited. Childhood adversities...

journal_title：Depression and anxiety

authors： Kim SW,Kang HJ,Kim SY,Kim JM,Yoon JS,Jung SW,Lee MS,Yim HW,Jun TY

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:This study examined the feasibility and preliminary effectiveness of d-cycloserine (DCS)-augmented cognitive behavioral therapy (CBT) for children and adolescents with difficult-to-treat Obsessive Compulsive Disorder, in a double-blind randomized controlled pilot trial (RCT). METHODS:Seventeen children and ...

journal_title：Depression and anxiety

authors： Farrell LJ,Waters AM,Boschen MJ,Hattingh L,McConnell H,Milliner EL,Collings N,Zimmer-Gembeck M,Shelton D,Ollendick TH,Testa C,Storch EA

更新日期：2013-08-01 00:00:00